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Saturated golden hues prevail in the living room, which looks out to ships en route to the canal. The 1973 aquatint is by Joan Miró. Oriental carpets from FJ Hakimian.

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For the hall, "I played with vaulting and coloring," says the designer, who worked with architect Ignacio Mallol and interior painter Antonio Rimada. The canvas at rear is by Venancio Shinki.

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"Good design has lots of layers—color, texture, types of furniture," says Botero.

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"I referenced Old Panama," Botero says of the room, which features stone floors grained to resemble wood. "Draperies with valances relax the hard edge." Gilt-iron table from Profiles. Clarence House drapery fabric; Donghia stripe. Carpets from FJ Hakimian.

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A seating area in the enclosed terrace takes in distant views.

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A white bedroom is "cool and soothing," Botero notes. The painting is by Jorge Montealegre. Drapery stripe from Cowtan Tout. Night table from FP Victoria Son. Stark carpet.

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In the hall, lanterns, from Holly Hunt, create "a delicate shadow pattern reminiscent of Baroque plasterwork." Edelman leather on chairs at rear.

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Over the vanity is an octagonal mirror by Karl Springer.